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VOL. 11, ISSUE 2 (2026)
Effect of quercetin supplementation on hepatotoxicity and oxidative stress in N-Nitrosodiethylamine (NDEA)-induced hepatic injury in rats
Authors
Fakruddin Khan, Dr. Fahad Ali
Abstract
The present study investigated the protective
effect of quercetin supplementation on hepatotoxicity and oxidative stress
induced by N-Nitrosodiethylamine (NDEA) in male Wistar rats. Thirty-six rats
were divided into six groups and treated with NDEA, quercetin, or their
combinations for 21 days. NDEA administration resulted in marked hepatic
damage, as indicated by significant elevations in serum liver enzymes (AST,
ALT, and ALP), total bilirubin, and lipid peroxidation levels, along with
depletion of endogenous antioxidant defenses such as superoxide dismutase
(SOD), catalase (CAT), and reduced glutathione (GSH). In contrast, quercetin
supplementation, particularly at higher doses, significantly restored
biochemical parameters toward normal levels and enhanced antioxidant enzyme
activities. Histopathological observations further supported the biochemical
findings by showing reduced necrosis, inflammation, and cellular degeneration
in the quercetin-treated groups. Overall, the results demonstrated that quercetin
exerted a strong hepatoprotective effect by mitigating oxidative damage and
improving the antioxidant defense system in NDEA-induced hepatic injury in
rats.
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Pages:133-138
How to cite this article:
Fakruddin Khan, Dr. Fahad Ali "Effect of quercetin supplementation on hepatotoxicity and oxidative stress in N-Nitrosodiethylamine (NDEA)-induced hepatic injury in rats". International Journal of Zoology Studies, Vol 11, Issue 2, 2026, Pages 133-138
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