The present study investigates seasonal variations in biochemical constituents—glycogen, proteins, and lipids—in different body tissues of the terrestrial snail Macrochlamys petrosa. Specimens were collected monthly and grouped into pre-reproductive, reproductive, post-reproductive, and aestivation phases. Biochemical analysis of foot, mantle, hepatopancreatic gonadal complex, and albumen gland revealed significant seasonal fluctuations. Glycogen and protein levels were highest during the pre-reproductive phase and declined during reproductive activity, indicating utilization for gametogenesis. Lipid reserves also showed a similar trend, with depletion during reproduction and accumulation prior to aestivation. These findings demonstrate a strong correlation between biochemical reserves and reproductive cycle, highlighting adaptive physiological strategies of M. petrosa in response to environmental changes.