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VOL. 11, ISSUE 2 (2026)
Evaluation of reproductive toxicity in Alloxan-induced diabetic albino mice and protective influence of Coriandrum sativum leaves
Authors
Sneha, Dr. Dinesh Yadav
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by
persistent hyperglycemia resulting from impaired insulin secretion, insulin
action, or both. The prevalence of diabetes has increased considerably
worldwide and it has become a major public health concern. Long-term
hyperglycemia is associated with various complications affecting different
organ systems, including the reproductive system. Several experimental and
clinical studies have reported that diabetes adversely affects male
reproductive function by impairing spermatogenesis, reducing sperm quality, and
altering hormonal balance. Hyperglycemia-induced oxidative stress plays a
significant role in damaging reproductive tissues and reducing fertility
potential. The present study was undertaken to evaluate the adverse effects of
alloxan-induced hyperglycemia on reproductive parameters of albino mice and to
investigate the protective role of Coriandrum sativum leaf extract.
Adult male albino mice weighing 25–30 g were selected and divided into three
groups: control, diabetic, and treatment groups. Diabetes was induced by
intraperitoneal injection of alloxan monohydrate. After confirmation of
hyperglycemia, coriander leaf extract was administered orally to the treatment
group for a specified period. The experimental animals were maintained under
standard laboratory conditions and monitored regularly. Reproductive
parameters such as body weight, testicular weight, sperm count, and sperm
motility were assessed at the end of the experimental period. The diabetic
group showed significant reduction in body weight and reproductive organ weight
compared to control animals. Sperm count and motility were markedly decreased
in alloxan-induced diabetic mice, indicating impairment of spermatogenesis.
These findings suggest that hyperglycemia has a detrimental effect on male
reproductive function. Treatment with Coriandrum sativum leaf extract resulted in
noticeable improvement in reproductive indices. The treated animals exhibited
increase in body weight, testicular weight, sperm count, and sperm motility
compared to diabetic group. The improvement observed in treatment group may be
attributed to antioxidant and hypoglycemic properties of coriander leaves.
Bioactive compounds present in coriander may help reduce oxidative stress and
restore reproductive function. The study concludes that Coriandrum
sativum leaves exhibit protective effects against reproductive toxicity caused
by hyperglycemia. The findings suggest that coriander leaf extract may serve as
a potential natural therapeutic agent for reducing reproductive complications
associated with diabetes. Further studies are required to evaluate biochemical
and hormonal parameters to understand the exact mechanism involved in the
protective action of coriander leaves.
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Pages:17-20
How to cite this article:
Sneha, Dr. Dinesh Yadav "Evaluation of reproductive toxicity in Alloxan-induced diabetic albino mice and protective influence of <i>Coriandrum sativum </i>leaves". International Journal of Zoology Studies, Vol 11, Issue 2, 2026, Pages 17-20
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