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VOL. 10, ISSUE 3 (2025)
Decoding Lumpy Skin Disease Virus: Molecular insights for diagnostics and disease management
Authors
Saujanya Pallewad, DB Bhure, SS Nanware, Shankar Mutkule
Abstract
Lumpy Skin Disease Virus (LSDV), a member of the Capripoxvirus
genus within the Poxviridae family, is a double-stranded DNA virus
responsible for severe economic losses in the cattle industry due to its high
morbidity and impact on livestock productivity. The genome of LSDV,
approximately 151 kbp in size, encodes a diverse array of genes involved in
viral replication, host range determination, immune modulation, and virulence.
Recent advancements in molecular biology and genomics have enabled the detailed
characterization of the genetic architecture of LSDV, uncovering critical
insights into its pathogenic mechanisms, genetic variability, and evolutionary
dynamics. This review synthesizes the current knowledge on the genetic basis of
LSDV, focusing on the functional roles of key genes, mechanisms of immune
evasion, and genetic determinants of virulence. Additionally, it highlights the
utility of genomic tools in outbreak tracing, disease diagnosis, and vaccine
development. Key findings emphasize the role of genomic stability in LSDV's
persistence and the emerging challenges posed by strain variation and host
adaptability. The review further addresses unresolved genomic questions by
outlining the gaps in current knowledge and proposing future research
directions, this article aims to contribute to the development of targeted
molecular interventions and enhance the global effort toward effective control
and eradication of LSDV.
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Pages:91-97
How to cite this article:
Saujanya Pallewad, DB Bhure, SS Nanware, Shankar Mutkule "Decoding Lumpy Skin Disease Virus: Molecular insights for diagnostics and disease management". International Journal of Zoology Studies, Vol 10, Issue 3, 2025, Pages 91-97
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