Biological activity of essences from Annona senegalensis leaves was evaluated in laboratory, on various stages of development of Caryedon serratus, a pest of groundnut stocks. The tested essences are obtained by steeping the powder with three solvents (methanol, hexane and ethyl acetate). The acetate fraction kills 100% of the eggs with 0.1g/ml whereas the methanol fraction kills 33% with 0.01g/ml. The crude extract and the hexane fraction have been shown to be ineffective but lead to a reduction of larval lifetime. Chrysalis lifetime and fecundity of the survivors are not modified by the various extracts; however, an increase in longevity is noted with all extracts. On adults, the effect depends on the extract and the dose used. After 72 h at high concentration, the crude extract and the methanol fraction eliminate 75% and 94% of insects, respectively; with a concentration of 0.01g/ml, the crude extract and the hexane fraction kill 75.86% and 47.22% of the insects, respectively, and at low concentration (0.001 g/ml) the acetate fraction acts and eliminates 94 %. Methanol and acetate fractions could be used in stocks protection, by applying them at the early infestation and at the period of emergence of the surviving adults.