Present study was carried out to investigate the immunological changes in goats infected with gastrointestinal nematode at Barwani District (M.P). Selected villages were Barwani, Sendhwa, Niwali, Pansemal and Khetia. Trichuis and Haemonchus nematodes were selected as experimental parasite. For Immunological study ITH and DTH response were noted in both control and experimental groups. In the present study with the constant dose of somatic antigens, we observed different ITH and DTH response in selected areas. This showed that goats of different area may have different response against somatic antigen. In the experiment animal ITH and DTH response increased as compared to control values. Increase ITH response showed the humeral immunity and increase DTH response showed the cell mediated immunity in the host against parasite and parasitic secretion.