The current examination was done to research the impacts of cypermethrin (cyano phenoxy benzyl pyrethroids, ordered as limited use pesticide (RUP) by US EPA due to its high poisonousness to angle) on gill histopathology in Anabas testudineus. Histopathological changes in gills, such as clubbing of cells, hyperplasia, combination of auxiliary lamellae followed by serious blood clog and degeneration of essential and optional gill lamellae affirm the poisonous impacts of cypermethrin in the test fish.