Diagnostic significance of MLSE Elisa in indeterminate leprosy
Archana Singh, Dr. Sandesh B Singh
Introduction: Early detection and treatment can be beneficial for the check and progress of the disease in the community so we planned to tackle the disease in very early stage. Indeterminate stage is the earliest stage so it is very easier to treat this disease at this stage. Materials and Methods: The study was carried out at the skin outpatients department (OPD) and immunology unit of Department of Pathology, K.G.’s Medical College, Lucknow from October 1998 to Dec. 2001. Result: In our study we observed MLSE ELISA had a higher sensitivity in cases of indeterminate (87%) while specificity was 100% ELISA for detection of IgM antibodies to PGL-1 antigen had a lower sensitivity of 62.6% and specificity was 100%. Detection of IgM antibody against MLSE antigen of total case serum of spectral group had higher sensitivity 89% than sensitivity of PGL-1 antigen 87% specificity of both antigen were same. Conclusion: Detection of antibody levels appeared to be useful in the diagnosis and to confirm the indeterminate leprosy from other groups of spectrum.