The therapeutic use of animal, animals' parts and their byproducts by ethnic groups to cure different diseases is known as ethno-medicine. In Nepal there are more than 100 ethnic groups; most of them are using surrounding natural resources to cure many diseases using traditional knowledge. Crabs are consumed not only to fulfill the nutrient requirements but also to cure diseases. This review was done to know the use of crab to cure various disease throughout the world and found using many crabs to cure disease like Asthma, miscarriage problems in women, typhoid, dysentery, liver disease, healing wound, bronchitis, pneumonia, osteoporosis, boils, womb disorders, tuberculosis, earache, burns, epilepsy and reproductive malfunction.