Effect of lead acetate and recovery response of DMSA on protein metabolism in liver and brain of freshwater fish, Channa striatus (BLOCH)
Vijaya Francis, M Muthulingam
Today man is living in a chemical sphere and these chemicals whether, natural or manmade, has the capacity to degrade the delicately balanced ecosystem by poisoning air, water and land. Heavy metals such as lead and cadmium have no nutritional importance, and their presence in relatively high concentration in body tissues can result in health problems in human as well as in animals. Lead is a non-essential metal and is a common historical and contemporary contaminant throughout the world. This element is one of the most ubiquitous and a useful metal known to humans and it is detectable in practically all phases of the inert environment and in all biological systems. The main route of exposure for general population is food and air. Fish are considered as an important source of high quality animal protein as they contain large amounts of essential amino acids. Also, fish contain crude lipids, which supply the body with energy and essential fatty acids that are necessary for life and play an important role in regulation of the cardio-vascular system and for reducing cholestrol level in the blood. Moreover, fish are rich in fat-soluble vitamins, iodine and phosphorous. The aim of the present study was to assess the protein and amino acid levels in liver and brain of Channa striatuswas exposed to sublethal concentration of lead acetate further the fish treated with meso 2,3- dimercapto succinic acid (DMSA) 2.5 ppm and 5 ppm in group 3 and group 4 respectively for the period of 10, 20 and 30 days. The fish exposed to lead acetate showed a decrease the protein and increase the amino acid levels further the fish were treated with dimercaptosuccinic acid showed gradually the protein contents increased and amino acid levels were decreased for the periods of 10, 20 and 30 days in liver and brain. The objective of the present investigation was to observe the reversing ability of dimercaptosuccinic acid reduced the lead acetate induced alterations in protein and amino acid in the liver and brain of freshwater fish, Channa striatus.