Heavy metal pollution in fresh water aquatic systems is a threat for ecosystem as well as for human health and economy. Various routes of contamination of Cd, Hg and Pb have been reported. Cd, Hg and Pb are so dangerous and harmful because of their persistent nature. Cadmium among these three culprits is the most dangerous contaminant that adversely affects growth, reproduction and behaviour of fresh water fishes. Mercury is a potent endocrine disrupter that vigorously impacts on fish reproduction and metabolism. Lead is a neurotoxicant that create behavioural disputes in fish population.