Increase of tuberculosis disease depends on the interaction of human host and mycobacterial stain. The adenosine triphosphate mediated purinergic P2X7 receptors kill the intracellular Mycobacterium tuberculosis and cell death occur of the infected macrophage. Only a single nucleotide polymorphism at the exon 13 of P2X7 1513A/C gene can change the function of this receptor and increased the risk of tuberculosis in tribal population of Jhargram. The P2X7 1513A/C gene polymorphism has been studied on TB infected (n=56) and non-TB (n=60) individuals and the CC genotype has significantly vast chance to occur tuberculosis (P<0.05). Consequences of this research plan established that CC genotype of P2X7 polymorphism is related with susceptibility to TB in contaminated patients of that.