The current study was achieved by measure the total protein concentrations on variations of ecological conditions or impact of natural conditions on various seasons in the protein content in soft body tissues of Corbicula Regularis of were collected from Jayakwadi dam, at Aurangabad district was observed during different seasons. It was variations of the climatic change in environment, Fluctuation of the protein content on its impact on various types of tissues, such as like, Mantle, Hepatopancreas, Gonad and foot. The Protein content maximum found in gonads tissues throughout all the three seasons, whereas mantle shows minimum values of protein. There are great variations in the values of protein during different seasons in ecological conditions.