Solanum trilobatum and Ocimum sanctum are the valuable medicinal plants. They are good immunostimulants. The purpose of this study to confirm the synergistic effect of aqueous methanolic extract of Solanum trilobatum and Ocimum sanctum individually and in combination on non-specific immune response of the fresh water fish Channa striatus through oral administration. Solanum trilobatum, Ocimum sanctum individually and in combination were mixed thoroughly with the artificial feeds at concentrations of 0.0%, 0.03%, 0.3%, 3.0% of dry diet. The prepared diets were fed to healthy C.striatus for 40 days.Non-specific immune response such as Total WBC count and Phagocytic activity were analysed. The oral administration of plant extract with their diet increased their total WBC count and Phagocytic activity significantly. The total WBC count and Phagocytic activity were significantly increased in the mixture plant extract treated fish in 1:1 ratio than the individual plant extract treated fish. The present study proved that the mixture of plant extracts in 1:1 ratio treated group increased nonspecific immune responses when compare with individual extract.