International Journal of Zoology Studies

International Journal of Zoology Studies


ISSN: 2455-7269

Vol. 4, Issue 3 (2019)

Possible functionality of start and stop codons present at specific and conserved positions in animal mitochondrial genes specifying tRNA

Author(s): Eric Faure, Roxane-Marie Barthélémy
Abstract: Several metazoan mitochondrial-trn genes (specifying tRNA) exhibit nucleotide triplets at specific and conserved positions corresponding to stop codons (TAG/TAA) and/or start codons (ATG/ATA). The products of these genes, which bear one or two types of these codons are called ss-tRNAs (for stop/start). In this article, several examples of ss-trn genes bearing start or stop codons in metazoans (protostomes and deuterostomes) strongly suggest that these codons are functional. Moreover, the ss-trn genes found in apicoplast genomes likely have a mitochondrial origin, but the TAR and ATR triplets (R for purines) found in their sequences seem to play only a structural role. Future investigations should attempt to clarify the mechanisms of the transcription and maturation of ss-trn genes with their overlapping protein genes and the possible regulatory roles of stop and start codons found in trn sequences.
Pages: 23-29  |  120 Views  41 Downloads
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