Vol. 3, Issue 6 (2018)
Study on lymphocyte migration inhibition factors in mice experimentally infected and vaccinated with Aspicularis tetraptera
Author(s): M Varma, S Gaherwal, MM Prakash
Abstract: Present study deals with the immune response and effectors mechanism which was confirmed by MIF (Migration Inhibition Factor). For MIF assay, lymphocytes were separated from heparinized blood of experimental and control mice. MIF reaction was maximum (16.4) mm in the group IVEgSoAg5 and minimum (10.2) mm in the group IVEgSoAg1. So the maximum and minimum MIF reaction was shown by Egg Somatic antigen Ag5 (100 μg) and Ag1 (20 μg) respectively. The results showed that the Migration Inhibition Factor is directly proportional to the vaccination dose, in other words the reaction was dose dependent. Somatic antigens were highly potent in stimulating an effective cell mediated response as evident by greater migration inhibition of lymphocytes in response of somatic antigen of eggs stage. Increased MIF value playing an important role in imparting effective cell mediated immunity.